Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues
نویسندگان
چکیده
In this study, a variety of original ligands related to Combretastatin A-4 and isoCombretastatin A-4, able inhibit the tubulin polymerization into microtubules, was designed, synthesized, evaluated. Our lead compound 15d having quinazoline as A-ring 2-substituted indole B-ring separated by N-methyl linker displayed remarkable sub-nanomolar level cytotoxicity (IC50 < 1 nM) against 9 human cancer cell lines.
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2021
ISSN: ['0009-4374']
DOI: https://doi.org/10.1016/j.ejmech.2021.113656